diff --git a/docs/usage/security.md b/docs/usage/security.md
index 1e85a4a2d..b126d2a1e 100644
--- a/docs/usage/security.md
+++ b/docs/usage/security.md
@@ -231,6 +231,18 @@ The most effective approach is to deploy vLLM behind a reverse proxy (such as ng
 - Blocks all other endpoints, including the unauthenticated inference and operational control endpoints
 - Implements additional authentication, rate limiting, and logging at the proxy layer
 
+## Request Parameter Resource Limits
+
+Certain API request parameters can have a large impact on resource consumption and may be abused to exhaust server resources. The `n` parameter in the `/v1/completions` and `/v1/chat/completions` endpoints controls how many independent output sequences are generated per request. A very large value causes the engine to allocate memory, CPU, and GPU time proportional to `n`, which can lead to out-of-memory conditions on the host and block the server from processing other requests.
+
+To mitigate this, vLLM enforces a configurable upper bound on the `n` parameter via the `VLLM_MAX_N_SEQUENCES` environment variable (default: **16384**). Requests exceeding this limit are rejected before reaching the engine.
+
+### Recommendations
+
+- **Public-facing deployments:** Consider setting `VLLM_MAX_N_SEQUENCES` to a value appropriate for your workload (e.g., `64` or `128`) to limit the blast radius of a single request.
+- **Reverse proxy layer:** In addition to vLLM's built-in limit, consider enforcing request body validation and rate limiting at your reverse proxy to further constrain abusive payloads.
+- **Monitoring:** Monitor per-request resource consumption to detect anomalous patterns that may indicate abuse.
+
 ## Tool Server and MCP Security
 
 vLLM supports connecting to external tool servers via the `--tool-server` argument. This enables models to call tools through the Responses API (`/v1/responses`). Tool server support works with all models — it is not limited to specific model architectures.
diff --git a/tests/entrypoints/openai/chat_completion/test_chat.py b/tests/entrypoints/openai/chat_completion/test_chat.py
index 25f4c7d7a..212839f78 100644
--- a/tests/entrypoints/openai/chat_completion/test_chat.py
+++ b/tests/entrypoints/openai/chat_completion/test_chat.py
@@ -1020,3 +1020,114 @@ def test_chat_completion_request_n_parameter_various_values():
         assert sampling_params.n == n_value, (
             f"Expected n={n_value}, got n={sampling_params.n}"
         )
+
+
+def test_chat_completion_request_n_parameter_exceeds_default_limit(
+    monkeypatch: pytest.MonkeyPatch,
+):
+    """Test that n values exceeding the default limit are rejected."""
+    import vllm.envs as envs
+
+    monkeypatch.delenv("VLLM_MAX_N_SEQUENCES", raising=False)
+    if hasattr(envs.__getattr__, "cache_clear"):
+        envs.__getattr__.cache_clear()
+
+    max_n = envs.VLLM_MAX_N_SEQUENCES
+    request = ChatCompletionRequest(
+        model="test-model",
+        messages=[{"role": "user", "content": "Test"}],
+        n=max_n + 1,
+        max_tokens=10,
+    )
+
+    with pytest.raises(ValueError, match="n must be at most"):
+        request.to_sampling_params(
+            max_tokens=10,
+            default_sampling_params={},
+        )
+
+
+def test_chat_completion_request_n_parameter_at_limit(
+    monkeypatch: pytest.MonkeyPatch,
+):
+    """Test that n at exactly the limit is accepted."""
+    import vllm.envs as envs
+
+    monkeypatch.delenv("VLLM_MAX_N_SEQUENCES", raising=False)
+    if hasattr(envs.__getattr__, "cache_clear"):
+        envs.__getattr__.cache_clear()
+
+    max_n = envs.VLLM_MAX_N_SEQUENCES
+    request = ChatCompletionRequest(
+        model="test-model",
+        messages=[{"role": "user", "content": "Test"}],
+        n=max_n,
+        max_tokens=10,
+    )
+
+    sampling_params = request.to_sampling_params(
+        max_tokens=10,
+        default_sampling_params={},
+    )
+    assert sampling_params.n == max_n
+
+
+def test_chat_completion_request_n_parameter_custom_limit(
+    monkeypatch: pytest.MonkeyPatch,
+):
+    """Test that VLLM_MAX_N_SEQUENCES env var overrides the default limit."""
+    import vllm.envs as envs
+
+    monkeypatch.setenv("VLLM_MAX_N_SEQUENCES", "128")
+    if hasattr(envs.__getattr__, "cache_clear"):
+        envs.__getattr__.cache_clear()
+
+    request = ChatCompletionRequest(
+        model="test-model",
+        messages=[{"role": "user", "content": "Test"}],
+        n=128,
+        max_tokens=10,
+    )
+
+    sampling_params = request.to_sampling_params(
+        max_tokens=10,
+        default_sampling_params={},
+    )
+    assert sampling_params.n == 128
+
+    request_over = ChatCompletionRequest(
+        model="test-model",
+        messages=[{"role": "user", "content": "Test"}],
+        n=129,
+        max_tokens=10,
+    )
+
+    with pytest.raises(ValueError, match="n must be at most 128"):
+        request_over.to_sampling_params(
+            max_tokens=10,
+            default_sampling_params={},
+        )
+
+
+def test_chat_completion_request_n_parameter_massive_value(
+    monkeypatch: pytest.MonkeyPatch,
+):
+    """Test that astronomically large n values are rejected (CVE fix)."""
+    import vllm.envs as envs
+
+    monkeypatch.delenv("VLLM_MAX_N_SEQUENCES", raising=False)
+    if hasattr(envs.__getattr__, "cache_clear"):
+        envs.__getattr__.cache_clear()
+
+    request = ChatCompletionRequest(
+        model="test-model",
+        messages=[{"role": "user", "content": "Test"}],
+        n=100_000_000,
+        max_tokens=1,
+    )
+
+    with pytest.raises(ValueError, match="n must be at most"):
+        request.to_sampling_params(
+            max_tokens=1,
+            default_sampling_params={},
+        )
diff --git a/tests/test_envs.py b/tests/test_envs.py
index b6b7cf38d..3f3add2ab 100644
--- a/tests/test_envs.py
+++ b/tests/test_envs.py
@@ -454,3 +454,55 @@ class TestVllmConfigureLogging:
 
             with pytest.raises(ValueError, match="invalid literal for int"):
                 _ = envs.VLLM_CONFIGURE_LOGGING
+
+
+class TestVllmMaxNSequences:
+    def test_default_value(self):
+        """Test that VLLM_MAX_N_SEQUENCES defaults to 64."""
+        with patch.dict(os.environ, {}, clear=False):
+            os.environ.pop("VLLM_MAX_N_SEQUENCES", None)
+            if hasattr(envs.__getattr__, "cache_clear"):
+                envs.__getattr__.cache_clear()
+
+            assert envs.VLLM_MAX_N_SEQUENCES == 16384
+
+    def test_custom_value(self, monkeypatch: pytest.MonkeyPatch):
+        """Test that VLLM_MAX_N_SEQUENCES can be overridden."""
+        monkeypatch.setenv("VLLM_MAX_N_SEQUENCES", "128")
+        if hasattr(envs.__getattr__, "cache_clear"):
+            envs.__getattr__.cache_clear()
+
+        assert envs.VLLM_MAX_N_SEQUENCES == 128
+
+    def test_sampling_params_respects_limit(
+        self,
+        monkeypatch: pytest.MonkeyPatch,
+    ):
+        """Test that SamplingParams rejects n above the limit."""
+        from vllm.sampling_params import SamplingParams
+
+        monkeypatch.delenv("VLLM_MAX_N_SEQUENCES", raising=False)
+        if hasattr(envs.__getattr__, "cache_clear"):
+            envs.__getattr__.cache_clear()
+
+        max_n = envs.VLLM_MAX_N_SEQUENCES
+        SamplingParams(n=max_n)
+
+        with pytest.raises(ValueError, match="n must be at most"):
+            SamplingParams(n=max_n + 1)
+
+    def test_sampling_params_respects_custom_limit(
+        self,
+        monkeypatch: pytest.MonkeyPatch,
+    ):
+        """Test that SamplingParams uses the overridden env var limit."""
+        from vllm.sampling_params import SamplingParams
+
+        monkeypatch.setenv("VLLM_MAX_N_SEQUENCES", "128")
+        if hasattr(envs.__getattr__, "cache_clear"):
+            envs.__getattr__.cache_clear()
+
+        SamplingParams(n=128)
+
+        with pytest.raises(ValueError, match="n must be at most 128"):
+            SamplingParams(n=129)
diff --git a/vllm/envs.py b/vllm/envs.py
index d29e367bc..2944bb111 100755
--- a/vllm/envs.py
+++ b/vllm/envs.py
@@ -86,6 +86,7 @@ if TYPE_CHECKING:
     VLLM_ALLOW_LONG_MAX_MODEL_LEN: bool = False
     VLLM_RPC_TIMEOUT: int = 10000  # ms
     VLLM_HTTP_TIMEOUT_KEEP_ALIVE: int = 5  # seconds
+    VLLM_MAX_N_SEQUENCES: int = 16384
     VLLM_PLUGINS: list[str] | None = None
     VLLM_LORA_RESOLVER_CACHE_DIR: str | None = None
     VLLM_LORA_RESOLVER_HF_REPO_LIST: str | None = None
@@ -870,6 +871,12 @@ environment_variables: dict[str, Callable[[], Any]] = {
     "VLLM_HTTP_TIMEOUT_KEEP_ALIVE": lambda: int(
         os.environ.get("VLLM_HTTP_TIMEOUT_KEEP_ALIVE", "5")
     ),
+    # Maximum allowed value for the `n` sampling parameter (number of output
+    # sequences per request). Limits resource consumption to prevent
+    # denial-of-service via excessively large fan-out. Default: 16384.
+    "VLLM_MAX_N_SEQUENCES": lambda: int(
+        os.environ.get("VLLM_MAX_N_SEQUENCES", "16384")
+    ),
     # a list of plugin names to load, separated by commas.
     # if this is not set, it means all plugins will be loaded
     # if this is set to an empty string, no plugins will be loaded
diff --git a/vllm/sampling_params.py b/vllm/sampling_params.py
index dc3e1d49c..3a2a04fd7 100644
--- a/vllm/sampling_params.py
+++ b/vllm/sampling_params.py
@@ -12,6 +12,7 @@ from typing import Any
 import msgspec
 from pydantic.dataclasses import dataclass
 
+import vllm.envs as envs
 from vllm.config import ModelConfig, SpeculativeConfig, StructuredOutputsConfig
 from vllm.exceptions import VLLMValidationError
 from vllm.logger import init_logger
@@ -169,6 +170,9 @@ class SamplingParams(
     n: int = 1
     """Number of outputs to return for the given prompt request.
 
+    The maximum allowed value is controlled by the ``VLLM_MAX_N_SEQUENCES``
+    environment variable (default: 16384).
+
     NOTE:
         `AsyncLLM` streams outputs by default. When `n > 1`, all `n` outputs
         are generated and streamed cumulatively per request. To see all `n`
@@ -425,6 +429,13 @@ class SamplingParams(
             raise ValueError(f"n must be an int, but is of type {type(self.n)}")
         if self.n < 1:
             raise ValueError(f"n must be at least 1, got {self.n}.")
+        max_n = envs.VLLM_MAX_N_SEQUENCES
+        if self.n > max_n:
+            raise ValueError(
+                f"n must be at most {max_n}, got {self.n}. "
+                "To increase this limit, set the VLLM_MAX_N_SEQUENCES "
+                "environment variable."
+            )
         if not -2.0 <= self.presence_penalty <= 2.0:
             raise ValueError(
                 f"presence_penalty must be in [-2, 2], got {self.presence_penalty}."