diff --git a/cmake/cpu_extension.cmake b/cmake/cpu_extension.cmake
index 5a0980dcc..dde8cc207 100644
--- a/cmake/cpu_extension.cmake
+++ b/cmake/cpu_extension.cmake
@@ -13,28 +13,16 @@ endif()
 #
 # Define environment variables for special configurations
 #
-set(ENABLE_AVX2 $ENV{VLLM_CPU_AVX2})
-set(ENABLE_AVX512 $ENV{VLLM_CPU_AVX512})
-set(ENABLE_AVX512BF16 $ENV{VLLM_CPU_AVX512BF16})
-set(ENABLE_AVX512VNNI $ENV{VLLM_CPU_AVX512VNNI})
-set(ENABLE_AMXBF16 $ENV{VLLM_CPU_AMXBF16})
+set(ENABLE_X86_ISA $ENV{VLLM_CPU_X86})
 set(ENABLE_ARM_BF16 $ENV{VLLM_CPU_ARM_BF16})
 
 include_directories("${CMAKE_SOURCE_DIR}/csrc")
 
-
 set (ENABLE_NUMA TRUE)
 
 #
 # Check the compile flags
 #
-
-if (CMAKE_SYSTEM_PROCESSOR MATCHES "x86_64")
-    list(APPEND CXX_COMPILE_FLAGS
-        "-mf16c"
-    )
-endif()
-
 if(MACOSX_FOUND)
     list(APPEND CXX_COMPILE_FLAGS
         "-DVLLM_CPU_EXTENSION")
@@ -78,18 +66,6 @@ function(check_sysctl TARGET OUT)
     endif()
 endfunction()
 
-
-function (is_avx512_disabled OUT)
-    set(DISABLE_AVX512 $ENV{VLLM_CPU_DISABLE_AVX512})
-    if(DISABLE_AVX512 AND DISABLE_AVX512 STREQUAL "true")
-        set(${OUT} ON PARENT_SCOPE)
-    else()
-        set(${OUT} OFF PARENT_SCOPE)
-    endif()
-endfunction()
-
-is_avx512_disabled(AVX512_DISABLED)
-
 if (MACOSX_FOUND AND CMAKE_SYSTEM_PROCESSOR STREQUAL "arm64")
     message(STATUS "Apple Silicon Detected")
     set(APPLE_SILICON_FOUND TRUE)
@@ -97,8 +73,6 @@ if (MACOSX_FOUND AND CMAKE_SYSTEM_PROCESSOR STREQUAL "arm64")
     check_sysctl(hw.optional.neon ASIMD_FOUND)
     check_sysctl(hw.optional.arm.FEAT_BF16 ARM_BF16_FOUND)
 else()
-    find_isa(${CPUINFO} "avx2" AVX2_FOUND)
-    find_isa(${CPUINFO} "avx512f" AVX512_FOUND)
     find_isa(${CPUINFO} "Power11" POWER11_FOUND)
     find_isa(${CPUINFO} "POWER10" POWER10_FOUND)
     find_isa(${CPUINFO} "POWER9" POWER9_FOUND)
@@ -108,77 +82,32 @@ else()
     find_isa(${CPUINFO} "v" RVV_FOUND) # Check for RISC-V RVV support
 
     # Support cross-compilation by allowing override via environment variables
-    if (ENABLE_AVX2)
-        set(AVX2_FOUND ON)
-        message(STATUS "AVX2 support enabled via VLLM_CPU_AVX2 environment variable")
-    endif()
-    if (ENABLE_AVX512)
-        set(AVX512_FOUND ON)
-        message(STATUS "AVX512 support enabled via VLLM_CPU_AVX512 environment variable")
-    endif()
     if (ENABLE_ARM_BF16)
         set(ARM_BF16_FOUND ON)
         message(STATUS "ARM BF16 support enabled via VLLM_CPU_ARM_BF16 environment variable")
     endif()
 endif()
 
-if (AVX512_FOUND AND NOT AVX512_DISABLED)
-    list(APPEND CXX_COMPILE_FLAGS
+if (CMAKE_SYSTEM_PROCESSOR MATCHES "x86_64|amd64" OR ENABLE_X86_ISA)
+    set(ENABLE_X86_ISA ON)
+    if (NOT (CMAKE_CXX_COMPILER_ID STREQUAL "GNU" AND
+            CMAKE_CXX_COMPILER_VERSION VERSION_GREATER_EQUAL 12.3))
+        message(FATAL_ERROR "X86 backend requires gcc/g++ >= 12.3")
+    endif()
+    list(APPEND CXX_COMPILE_FLAGS "-mf16c")
+    list(APPEND CXX_COMPILE_FLAGS_AVX512 ${CXX_COMPILE_FLAGS})
+    list(APPEND CXX_COMPILE_FLAGS_AVX2 ${CXX_COMPILE_FLAGS})
+    list(APPEND CXX_COMPILE_FLAGS_AVX512
         "-mavx512f"
         "-mavx512vl"
         "-mavx512bw"
-        "-mavx512dq")
-
-    find_isa(${CPUINFO} "avx512_bf16" AVX512BF16_FOUND)
-    if (AVX512BF16_FOUND OR ENABLE_AVX512BF16)
-        if (CMAKE_CXX_COMPILER_ID STREQUAL "GNU" AND
-            CMAKE_CXX_COMPILER_VERSION VERSION_GREATER_EQUAL 12.3)
-            list(APPEND CXX_COMPILE_FLAGS "-mavx512bf16")
-            set(ENABLE_AVX512BF16 ON)
-        else()
-            set(ENABLE_AVX512BF16 OFF)
-            message(WARNING "Disable AVX512-BF16 ISA support, requires gcc/g++ >= 12.3")
-        endif()
-    else()
-        set(ENABLE_AVX512BF16 OFF)
-        message(WARNING "Disable AVX512-BF16 ISA support, no avx512_bf16 found in local CPU flags." " If cross-compilation is required, please set env VLLM_CPU_AVX512BF16=1.")
-    endif()
-
-    find_isa(${CPUINFO} "avx512_vnni" AVX512VNNI_FOUND)
-    if (AVX512VNNI_FOUND OR ENABLE_AVX512VNNI)
-        if (CMAKE_CXX_COMPILER_ID STREQUAL "GNU" AND
-            CMAKE_CXX_COMPILER_VERSION VERSION_GREATER_EQUAL 12.3)
-            list(APPEND CXX_COMPILE_FLAGS "-mavx512vnni")
-            set(ENABLE_AVX512VNNI ON)
-        else()
-            set(ENABLE_AVX512VNNI OFF)
-            message(WARNING "Disable AVX512-VNNI ISA support, requires gcc/g++ >= 12.3")
-        endif()
-    else()
-        set(ENABLE_AVX512VNNI OFF)
-        message(WARNING "Disable AVX512-VNNI ISA support, no avx512_vnni found in local CPU flags." " If cross-compilation is required, please set env VLLM_CPU_AVX512VNNI=1.")
-    endif()
-
-    find_isa(${CPUINFO} "amx_bf16" AMXBF16_FOUND)
-    if (AMXBF16_FOUND OR ENABLE_AMXBF16)
-        if (CMAKE_CXX_COMPILER_ID STREQUAL "GNU" AND
-            CMAKE_CXX_COMPILER_VERSION VERSION_GREATER_EQUAL 12.3)
-            list(APPEND CXX_COMPILE_FLAGS "-mamx-bf16" "-mamx-tile")
-            set(ENABLE_AMXBF16 ON)
-            add_compile_definitions(-DCPU_CAPABILITY_AMXBF16)
-        else()
-            set(ENABLE_AMXBF16 OFF)
-            message(WARNING "Disable AMX_BF16 ISA support, requires gcc/g++ >= 12.3")
-        endif()
-    else()
-        set(ENABLE_AMXBF16 OFF)
-        message(WARNING "Disable AMX_BF16 ISA support, no amx_bf16 found in local CPU flags." " If cross-compilation is required, please set env VLLM_CPU_AMXBF16=1.")
-    endif()
-    
-elseif (AVX2_FOUND)
-    list(APPEND CXX_COMPILE_FLAGS "-mavx2")
-    message(WARNING "vLLM CPU backend using AVX2 ISA")
-    
+        "-mavx512dq"
+        "-mavx512bf16"
+        "-mavx512vnni"
+        "-mamx-bf16"
+        "-mamx-tile")
+    list(APPEND CXX_COMPILE_FLAGS_AVX2
+        "-mavx2")
 elseif (POWER9_FOUND OR POWER10_FOUND OR POWER11_FOUND)
     message(STATUS "PowerPC detected")
     if (POWER9_FOUND)
@@ -219,12 +148,12 @@ elseif (CMAKE_SYSTEM_PROCESSOR MATCHES "riscv64")
         list(APPEND CXX_COMPILE_FLAGS "-march=rv64gc")
     endif()
 else()
-    message(FATAL_ERROR "vLLM CPU backend requires AVX512, AVX2, Power9+ ISA, S390X ISA, ARMv8 or RISC-V support.")
+    message(FATAL_ERROR "vLLM CPU backend requires X86, Power9+ ISA, S390X ISA, ARMv8 or RISC-V support.")
 endif()
 
 
-# Build oneDNN for GEMM kernels (only for x86-AVX512 /ARM platforms)
-if ((AVX512_FOUND AND NOT AVX512_DISABLED) OR (ASIMD_FOUND AND NOT APPLE_SILICON_FOUND) OR POWER9_FOUND OR POWER10_FOUND OR POWER11_FOUND)
+# Build oneDNN for GEMM kernels
+if (ENABLE_X86_ISA OR (ASIMD_FOUND AND NOT APPLE_SILICON_FOUND) OR POWER9_FOUND OR POWER10_FOUND OR POWER11_FOUND)
     # Fetch and build Arm Compute Library (ACL) as oneDNN's backend for AArch64
     # TODO [fadara01]: remove this once ACL can be fetched and built automatically as a dependency of oneDNN
     set(ONEDNN_AARCH64_USE_ACL OFF CACHE BOOL "")
@@ -329,13 +258,21 @@ if ((AVX512_FOUND AND NOT AVX512_DISABLED) OR (ASIMD_FOUND AND NOT APPLE_SILICON
     set(ONEDNN_ENABLE_WORKLOAD "INFERENCE")
     set(ONEDNN_ENABLE_PRIMITIVE "MATMUL;REORDER")
     set(ONEDNN_BUILD_GRAPH "OFF")
-    set(ONEDNN_ENABLE_JIT_PROFILING "OFF")
+    set(ONEDNN_ENABLE_JIT_PROFILING "ON")
     set(ONEDNN_ENABLE_ITT_TASKS "OFF")
-    set(ONEDNN_ENABLE_MAX_CPU_ISA "OFF")
-    set(ONEDNN_ENABLE_CPU_ISA_HINTS "OFF")
-    set(ONEDNN_VERBOSE "OFF")
+    set(ONEDNN_ENABLE_MAX_CPU_ISA "ON")
+    set(ONEDNN_ENABLE_CPU_ISA_HINTS "ON")
+    set(ONEDNN_VERBOSE "ON")
     set(CMAKE_POLICY_DEFAULT_CMP0077 NEW)
 
+    # TODO: Refactor this
+    if (ENABLE_X86_ISA)
+        # Note: only enable oneDNN for AVX512
+        list(APPEND DNNL_COMPILE_FLAGS ${CXX_COMPILE_FLAGS_AVX512})
+    else()
+        list(APPEND DNNL_COMPILE_FLAGS ${CXX_COMPILE_FLAGS})
+    endif()
+
     set(VLLM_BUILD_TYPE ${CMAKE_BUILD_TYPE})
     set(CMAKE_BUILD_TYPE "Release") # remove oneDNN debug symbols to reduce size
     FetchContent_MakeAvailable(oneDNN)
@@ -348,14 +285,20 @@ if ((AVX512_FOUND AND NOT AVX512_DISABLED) OR (ASIMD_FOUND AND NOT APPLE_SILICON
         PRIVATE ${oneDNN_SOURCE_DIR}/src
     )
     target_link_libraries(dnnl_ext dnnl torch)
-    target_compile_options(dnnl_ext PRIVATE ${CXX_COMPILE_FLAGS} -fPIC)
+    target_compile_options(dnnl_ext PRIVATE ${DNNL_COMPILE_FLAGS} -fPIC)
     list(APPEND LIBS dnnl_ext)
     set(USE_ONEDNN ON)
 else()
     set(USE_ONEDNN OFF)
 endif()
 
-message(STATUS "CPU extension compile flags: ${CXX_COMPILE_FLAGS}")
+# TODO: Refactor this
+if (ENABLE_X86_ISA)
+    message(STATUS "CPU extension (AVX512) compile flags: ${CXX_COMPILE_FLAGS_AVX512}")
+    message(STATUS "CPU extension (AVX2) compile flags: ${CXX_COMPILE_FLAGS_AVX2}")
+else()
+    message(STATUS "CPU extension compile flags: ${CXX_COMPILE_FLAGS}")
+endif()
 
 if(ENABLE_NUMA)
     list(APPEND LIBS numa)
@@ -390,25 +333,6 @@ set(VLLM_EXT_SRC
     "csrc/cpu/cpu_attn.cpp"
     "csrc/cpu/torch_bindings.cpp")
 
-if (AVX512_FOUND AND NOT AVX512_DISABLED)
-    set(VLLM_EXT_SRC
-        "csrc/cpu/shm.cpp"
-        "csrc/cpu/cpu_wna16.cpp"
-        "csrc/cpu/cpu_fused_moe.cpp"
-        ${VLLM_EXT_SRC})
-    if (ENABLE_AVX512BF16 AND ENABLE_AVX512VNNI)
-        set(VLLM_EXT_SRC
-            "csrc/cpu/sgl-kernels/gemm.cpp"
-            "csrc/cpu/sgl-kernels/gemm_int8.cpp"
-            "csrc/cpu/sgl-kernels/gemm_fp8.cpp"
-            "csrc/cpu/sgl-kernels/moe.cpp"
-            "csrc/cpu/sgl-kernels/moe_int8.cpp"
-            "csrc/cpu/sgl-kernels/moe_fp8.cpp"
-            ${VLLM_EXT_SRC})
-        add_compile_definitions(-DCPU_CAPABILITY_AVX512)
-    endif()
-endif()
-
 if (ASIMD_FOUND AND NOT APPLE_SILICON_FOUND)
     set(VLLM_EXT_SRC
         "csrc/cpu/shm.cpp"
@@ -421,21 +345,83 @@ if(USE_ONEDNN)
         ${VLLM_EXT_SRC})
 endif()
 
-message(STATUS "CPU extension source files: ${VLLM_EXT_SRC}")
+if (ENABLE_X86_ISA)
+    set(VLLM_EXT_SRC_AVX512
+        "csrc/cpu/sgl-kernels/gemm.cpp"
+        "csrc/cpu/sgl-kernels/gemm_int8.cpp"
+        "csrc/cpu/sgl-kernels/gemm_fp8.cpp"
+        "csrc/cpu/sgl-kernels/moe.cpp"
+        "csrc/cpu/sgl-kernels/moe_int8.cpp"
+        "csrc/cpu/sgl-kernels/moe_fp8.cpp"
+        "csrc/cpu/shm.cpp"
+        "csrc/cpu/cpu_wna16.cpp"
+        "csrc/cpu/cpu_fused_moe.cpp"
+        "csrc/cpu/utils.cpp"
+        "csrc/cpu/cpu_attn.cpp"
+        "csrc/cpu/dnnl_kernels.cpp"
+        "csrc/cpu/torch_bindings.cpp"
+        # TODO: Remove these files
+        "csrc/cpu/activation.cpp"
+        "csrc/cpu/layernorm.cpp"
+        "csrc/cpu/mla_decode.cpp"
+        "csrc/cpu/pos_encoding.cpp"
+        "csrc/moe/dynamic_4bit_int_moe_cpu.cpp") 
 
-#
-# Define extension targets
-#
+    set(VLLM_EXT_SRC_AVX2 
+        "csrc/cpu/utils.cpp"
+        "csrc/cpu/cpu_attn.cpp"
+        "csrc/cpu/torch_bindings.cpp"
+        # TODO: Remove these files
+        "csrc/cpu/activation.cpp"
+        "csrc/cpu/layernorm.cpp"
+        "csrc/cpu/mla_decode.cpp"
+        "csrc/cpu/pos_encoding.cpp"
+        "csrc/moe/dynamic_4bit_int_moe_cpu.cpp") 
 
-define_extension_target(
-    _C
-    DESTINATION vllm
-    LANGUAGE CXX
-    SOURCES ${VLLM_EXT_SRC}
-    LIBRARIES ${LIBS}
-    COMPILE_FLAGS ${CXX_COMPILE_FLAGS}
-    USE_SABI 3
-    WITH_SOABI
-)
+    message(STATUS "CPU extension (AVX512) source files: ${VLLM_EXT_SRC_AVX512}")
+    message(STATUS "CPU extension (AVX2) source files: ${VLLM_EXT_SRC_AVX2}")
+
+    define_extension_target(
+        _C
+        DESTINATION vllm
+        LANGUAGE CXX
+        SOURCES ${VLLM_EXT_SRC_AVX512}
+        LIBRARIES ${LIBS}
+        COMPILE_FLAGS ${CXX_COMPILE_FLAGS_AVX512}
+        USE_SABI 3
+        WITH_SOABI
+    )
+
+    # For SGL kernels
+    target_compile_definitions(_C PRIVATE "-DCPU_CAPABILITY_AVX512")
+    # For AMX kernels
+    target_compile_definitions(_C PRIVATE "-DCPU_CAPABILITY_AMXBF16")
+
+    define_extension_target(
+        _C_AVX2
+        DESTINATION vllm
+        LANGUAGE CXX
+        SOURCES ${VLLM_EXT_SRC_AVX2}
+        LIBRARIES ${LIBS}
+        COMPILE_FLAGS ${CXX_COMPILE_FLAGS_AVX2}
+        USE_SABI 3
+        WITH_SOABI
+    )
+else()
+    message(STATUS "CPU extension source files: ${VLLM_EXT_SRC}")
+    #
+    # Define extension targets
+    #
+    define_extension_target(
+        _C
+        DESTINATION vllm
+        LANGUAGE CXX
+        SOURCES ${VLLM_EXT_SRC}
+        LIBRARIES ${LIBS}
+        COMPILE_FLAGS ${CXX_COMPILE_FLAGS}
+        USE_SABI 3
+        WITH_SOABI
+    )
+endif()
 
 message(STATUS "Enabling C extension.")
diff --git a/csrc/cpu/torch_bindings.cpp b/csrc/cpu/torch_bindings.cpp
index 11e1305c6..2ea482148 100644
--- a/csrc/cpu/torch_bindings.cpp
+++ b/csrc/cpu/torch_bindings.cpp
@@ -4,6 +4,10 @@
 
 #include <torch/library.h>
 
+// Note: overwrite the external defination for sharing same name between
+// libraries use different ISAs.
+#define TORCH_EXTENSION_NAME _C
+
 std::string init_cpu_threads_env(const std::string& cpu_ids);
 
 void release_dnnl_matmul_handler(int64_t handler);
@@ -324,19 +328,12 @@ TORCH_LIBRARY_EXPAND(TORCH_EXTENSION_NAME, ops) {
       "str act, str isa) -> ()");
   ops.impl("cpu_fused_moe", torch::kCPU, &cpu_fused_moe);
 #endif
-}
-
-TORCH_LIBRARY_EXPAND(CONCAT(TORCH_EXTENSION_NAME, _utils), utils) {
-  // CPU utils
-  utils.def("init_cpu_threads_env(str cpu_ids) -> str", &init_cpu_threads_env);
-}
-
-TORCH_LIBRARY_EXPAND(CONCAT(TORCH_EXTENSION_NAME, _cpu), cpu_ops) {
-  cpu_ops.def(
+  ops.def("init_cpu_threads_env(str cpu_ids) -> str", &init_cpu_threads_env);
+  ops.def(
       "mla_decode_kvcache("
       "   Tensor! out, Tensor query, Tensor kv_cache,"
       "   float scale, Tensor block_tables, Tensor seq_lens) -> ()");
-  cpu_ops.impl("mla_decode_kvcache", torch::kCPU, &mla_decode_kvcache);
+  ops.impl("mla_decode_kvcache", torch::kCPU, &mla_decode_kvcache);
 }
 
 REGISTER_EXTENSION(TORCH_EXTENSION_NAME)
diff --git a/setup.py b/setup.py
index a6f2019e5..afdd4b19b 100644
--- a/setup.py
+++ b/setup.py
@@ -818,7 +818,7 @@ def _is_xpu() -> bool:
 
 
 def _build_custom_ops() -> bool:
-    return _is_cuda() or _is_hip() or _is_cpu()
+    return _is_cuda() or _is_hip()
 
 
 def get_rocm_version():
@@ -987,6 +987,15 @@ if _is_cuda():
             CMakeExtension(name="vllm._flashmla_extension_C", optional=True)
         )
 
+if _is_cpu():
+    import platform
+
+    if platform.machine() in ("x86_64", "AMD64"):
+        ext_modules.append(CMakeExtension(name="vllm._C"))
+        ext_modules.append(CMakeExtension(name="vllm._C_AVX2"))
+    else:
+        ext_modules.append(CMakeExtension(name="vllm._C"))
+
 if _build_custom_ops():
     ext_modules.append(CMakeExtension(name="vllm._C"))
 
diff --git a/vllm/_custom_ops.py b/vllm/_custom_ops.py
index 69f080ae2..46f9dfad9 100644
--- a/vllm/_custom_ops.py
+++ b/vllm/_custom_ops.py
@@ -178,9 +178,7 @@ def mla_decode_kvcache_cpu(
     block_tables: torch.Tensor,
     seq_lens: torch.Tensor,
 ) -> None:
-    torch.ops._C_cpu.mla_decode_kvcache(
-        out, query, kv_cache, scale, block_tables, seq_lens
-    )
+    torch.ops._C.mla_decode_kvcache(out, query, kv_cache, scale, block_tables, seq_lens)
 
 
 # merge attn states ops
diff --git a/vllm/platforms/cpu.py b/vllm/platforms/cpu.py
index b3d6b0ed6..421cf8797 100644
--- a/vllm/platforms/cpu.py
+++ b/vllm/platforms/cpu.py
@@ -483,3 +483,27 @@ class CpuPlatform(Platform):
     @classmethod
     def support_hybrid_kv_cache(cls) -> bool:
         return True
+
+    @classmethod
+    def import_kernels(cls) -> None:
+        if Platform.get_cpu_architecture() in (CpuArchEnum.X86,):
+            if torch._C._cpu._is_avx512_supported():
+                try:
+                    import vllm._C  # noqa: F401
+                except ImportError as e:
+                    logger.warning("Failed to import from vllm._C: %r", e)
+            else:
+                # Note: The lib name is _C_AVX2, but the module name is _C.
+                # This will cause a exception "dynamic module does define
+                # module export function". But the library is imported
+                # successfully. So ignore the exception for now, until we find
+                # a solution.
+                try:
+                    import vllm._C_AVX2  # noqa: F401
+                except ImportError as e:
+                    logger.warning("Failed to import from vllm._C_AVX2: %r", e)
+        else:
+            try:
+                import vllm._C  # noqa: F401
+            except ImportError as e:
+                logger.warning("Failed to import from vllm._C: %r", e)
diff --git a/vllm/v1/worker/cpu_worker.py b/vllm/v1/worker/cpu_worker.py
index 752b692f8..d0cecda29 100644
--- a/vllm/v1/worker/cpu_worker.py
+++ b/vllm/v1/worker/cpu_worker.py
@@ -85,7 +85,7 @@ class CPUWorker(Worker):
             self.local_omp_cpuid = omp_cpuids_list[self.rank]
 
         if self.local_omp_cpuid != "nobind":
-            ret = torch.ops._C_utils.init_cpu_threads_env(self.local_omp_cpuid)
+            ret = torch.ops._C.init_cpu_threads_env(self.local_omp_cpuid)
             if ret:
                 logger.info(ret)