diff --git a/setup.py b/setup.py
index 556a511a3..f31b4cf24 100644
--- a/setup.py
+++ b/setup.py
@@ -1056,6 +1056,7 @@ setup(
             "scipy",
             "soundfile",
             "mistral_common[audio]",
+            "av",
         ],  # Required for audio processing
         "video": [],  # Kept for backwards compatibility
         "flashinfer": [],  # Kept for backwards compatibility
diff --git a/vllm/model_executor/models/config.py b/vllm/model_executor/models/config.py
index ef241d545..ec03d283f 100644
--- a/vllm/model_executor/models/config.py
+++ b/vllm/model_executor/models/config.py
@@ -622,6 +622,15 @@ class NemotronHForCausalLMConfig(VerifyAndUpdateConfig):
             cache_config.mamba_ssm_cache_dtype = mamba_ssm_cache_dtype
 
 
+class NemotronHNanoVLV2Config(VerifyAndUpdateConfig):
+    @staticmethod
+    def verify_and_update_model_config(model_config: "ModelConfig") -> None:
+        mm_config = model_config.multimodal_config
+        if mm_config is not None:
+            video_kwargs = mm_config.media_io_kwargs.setdefault("video", {})
+            video_kwargs.setdefault("video_backend", "nemotron_vl")
+
+
 class Qwen3_5ForConditionalGenerationConfig(VerifyAndUpdateConfig):
     @staticmethod
     def verify_and_update_config(vllm_config: "VllmConfig") -> None:
@@ -661,6 +670,7 @@ MODELS_CONFIG_MAP: dict[str, type[VerifyAndUpdateConfig]] = {
     "GteNewModel": GteNewModelConfig,
     "GteNewForSequenceClassification": GteNewModelConfig,
     "Gemma3TextModel": Gemma3TextModelConfig,
+    "NemotronH_Nano_VL_V2": NemotronHNanoVLV2Config,
     "LlamaBidirectionalForSequenceClassification": LlamaBidirectionalConfig,
     "LlamaBidirectionalModel": LlamaBidirectionalConfig,
     "LlamaNemotronVLModel": LlamaNemotronVLConfig,
diff --git a/vllm/model_executor/models/nano_nemotron_vl.py b/vllm/model_executor/models/nano_nemotron_vl.py
index 82422e89f..9b9beadc0 100644
--- a/vllm/model_executor/models/nano_nemotron_vl.py
+++ b/vllm/model_executor/models/nano_nemotron_vl.py
@@ -59,9 +59,11 @@ from vllm.multimodal.inputs import (
     AudioItem,
     MultiModalDataDict,
     MultiModalFieldConfig,
+    MultiModalInputs,
     MultiModalKwargsItems,
     VideoItem,
 )
+from vllm.multimodal.media.audio import extract_audio_from_video_bytes
 from vllm.multimodal.parse import (
     AudioProcessorItems,
     ImageEmbeddingItems,
@@ -69,8 +71,13 @@ from vllm.multimodal.parse import (
     ImageSize,
     MultiModalDataItems,
     MultiModalDataParser,
+    VideoProcessorItems,
+)
+from vllm.multimodal.processing import (
+    BaseDummyInputsBuilder,
+    ProcessorInputs,
+    TimingContext,
 )
-from vllm.multimodal.processing import BaseDummyInputsBuilder
 from vllm.multimodal.processing.processor import (
     BaseMultiModalProcessor,
     BaseProcessingInfo,
@@ -1381,6 +1388,127 @@ class NanoNemotronVLMultiModalProcessor(
 ):
     """MultiModalProcessor extended for video support"""
 
+    def _extract_audio_from_videos(
+        self,
+        mm_items: MultiModalDataItems,
+    ) -> tuple[MultiModalDataItems, list[AudioItem]]:
+        """Extract audio tracks from video bytes in *mm_items*.
+
+        Returns:
+            The augmented *mm_items* (with audio added) and the list of
+            extracted audio items.
+        """
+        videos = mm_items.get_items("video", VideoProcessorItems)
+        assert isinstance(videos.metadata, list)
+        metadata_list = videos.metadata
+
+        audio_items: list[AudioItem] = []
+        for metadata in metadata_list:
+            video_bytes = metadata.get("original_video_bytes")
+            if video_bytes is None or len(video_bytes) == 0:
+                raise ValueError(
+                    "Cannot extract audio from video: original_video_bytes is "
+                    "missing or empty. When using use_audio_in_video=True, "
+                    "video must be loaded with keep_video_bytes=True (e.g. via "
+                    "the chat API with a model that sets use_audio_in_video)."
+                )
+            audio_items.append(extract_audio_from_video_bytes(video_bytes))
+
+        # Create a new VideoProcessorItems with metadata that does not contain
+        # the large video bytes, to avoid modifying the input `mm_items`.
+        new_metadata_list = [
+            {k: v for k, v in meta.items() if k != "original_video_bytes"}
+            for meta in metadata_list
+        ]
+        new_videos = VideoProcessorItems(data=videos.data, metadata=new_metadata_list)
+
+        audio_parsed = self.data_parser.parse_mm_data({"audio": audio_items})
+
+        # Create a new MultiModalDataItems with the new video and audio items.
+        new_mm_items_dict = {**mm_items, **audio_parsed, "video": new_videos}
+        mm_items = MultiModalDataItems(new_mm_items_dict)
+
+        return mm_items, audio_items
+
+    def apply(
+        self,
+        processor_inputs: ProcessorInputs,
+        timing_ctx: TimingContext | None = None,
+    ) -> MultiModalInputs:
+        if (hf_processor_mm_kwargs := processor_inputs.hf_processor_mm_kwargs) is None:
+            hf_processor_mm_kwargs = {}
+
+        use_audio_in_video = bool(
+            hf_processor_mm_kwargs.get("use_audio_in_video", False)
+        )
+
+        hf_processor_mm_kwargs = {
+            k: v for k, v in hf_processor_mm_kwargs.items() if k != "use_audio_in_video"
+        }
+
+        processor_inputs.hf_processor_mm_kwargs = hf_processor_mm_kwargs
+
+        if not (
+            use_audio_in_video
+            and "video" in processor_inputs.mm_data_items
+            and "audio" not in processor_inputs.mm_data_items
+        ):
+            return super().apply(
+                processor_inputs,
+                timing_ctx,
+            )
+
+        mm_items, audio_items = self._extract_audio_from_videos(
+            processor_inputs.mm_data_items
+        )
+        processor_inputs.mm_data_items = mm_items
+
+        prompt = processor_inputs.prompt
+        tokenizer = self.info.get_tokenizer()
+        if not isinstance(prompt, str):
+            prompt = tokenizer.decode(prompt, skip_special_tokens=False)
+
+        for _ in audio_items:
+            prompt = prompt.replace("<video>", "<video>" + AUDIO_CONTEXT, 1)
+
+        processor_inputs.prompt = tokenizer.encode(prompt, add_special_tokens=False)
+
+        if processor_inputs.tokenization_kwargs is None:
+            processor_inputs.tokenization_kwargs = {}
+
+        # Bypass the cached path: the HF processor must receive the
+        # prompt (with injected <so_embedding>) and the audio data
+        # together so it can perform audio-token replacement natively.
+        (
+            prompt_ids,
+            mm_info,
+            is_update_applied,
+        ) = self._apply_hf_processor(
+            processor_inputs,
+            timing_ctx=timing_ctx,
+        )
+
+        prompt_ids, mm_placeholders = self._maybe_apply_prompt_updates(
+            mm_items=mm_items,
+            prompt_ids=prompt_ids,
+            mm_kwargs=mm_info.kwargs,
+            mm_prompt_updates=mm_info.prompt_updates,
+            is_update_applied=is_update_applied,
+        )
+
+        mm_placeholder_ranges = {
+            modality: [item.to_range() for item in placeholders]
+            for modality, placeholders in mm_placeholders.items()
+        }
+
+        return MultiModalInputs(
+            type="multimodal",
+            prompt_token_ids=prompt_ids,
+            mm_kwargs=mm_info.kwargs,
+            mm_hashes=mm_info.hashes,
+            mm_placeholders=mm_placeholder_ranges,
+        )
+
     def _get_mm_fields_config(
         self,
         hf_inputs: BatchFeature,
diff --git a/vllm/multimodal/media/audio.py b/vllm/multimodal/media/audio.py
index 3a386c148..7f2327215 100644
--- a/vllm/multimodal/media/audio.py
+++ b/vllm/multimodal/media/audio.py
@@ -4,6 +4,7 @@ import base64
 from io import BytesIO
 from pathlib import Path
 
+import numpy as np
 import numpy.typing as npt
 import pybase64
 import torch
@@ -23,6 +24,63 @@ try:
 except ImportError:
     soundfile = PlaceholderModule("soundfile")  # type: ignore[assignment]
 
+try:
+    import av
+except ImportError:
+    av = PlaceholderModule("av")  # type: ignore[assignment]
+
+
+def extract_audio_from_video_bytes(
+    data: bytes,
+) -> tuple[npt.NDArray, float]:
+    """Extract the audio track from raw video bytes using PyAV.
+
+    PyAV wraps FFmpeg's C libraries in-process — no subprocess is
+    spawned, which is critical to avoid crashing CUDA-active vLLM
+    worker processes.
+
+    The returned waveform is at the native sample rate of the video's
+    audio stream.  Resampling to a model-specific rate is left to the
+    downstream :class:`AudioResampler` in the parsing pipeline.
+
+    Args:
+        data: Raw video file bytes (e.g. from an mp4 file).
+
+    Returns:
+        A tuple of ``(waveform, sample_rate)`` suitable for use as an
+        :class:`AudioItem`.
+    """
+    if data is None or len(data) == 0:
+        raise ValueError(
+            "Cannot extract audio: video bytes are missing or empty. "
+            "Ensure video was loaded with keep_video_bytes=True for "
+            "audio-in-video extraction."
+        )
+    try:
+        with av.open(BytesIO(data)) as container:
+            if not container.streams.audio:
+                raise ValueError("No audio stream found in the video.")
+            stream = container.streams.audio[0]
+            native_sr = stream.rate
+
+            chunks: list[npt.NDArray] = []
+            for frame in container.decode(audio=0):
+                arr = frame.to_ndarray()
+                chunks.append(arr.mean(axis=0) if arr.ndim > 1 else arr)
+    except ValueError:
+        raise
+    except Exception as e:
+        raise ValueError(
+            "Invalid or corrupted video data when extracting audio. "
+            "Ensure the input is valid video bytes (e.g. a complete MP4)."
+        ) from e
+
+    if not chunks:
+        raise ValueError("No audio found in the video.")
+
+    audio = np.concatenate(chunks).astype(np.float32)
+    return audio, float(native_sr)
+
 
 class AudioMediaIO(MediaIO[tuple[npt.NDArray, float]]):
     def __init__(self, **kwargs) -> None:
diff --git a/vllm/multimodal/video.py b/vllm/multimodal/video.py
index fb4e19fa6..bafdfbbbb 100644
--- a/vllm/multimodal/video.py
+++ b/vllm/multimodal/video.py
@@ -749,6 +749,33 @@ class Molmo2VideoBackend(VideoLoader):
         return out
 
 
+@VIDEO_LOADER_REGISTRY.register("nemotron_vl")
+class NemotronVLVideoBackend(OpenCVVideoBackend):
+    @classmethod
+    def load_bytes(
+        cls,
+        data: bytes,
+        num_frames: int = -1,
+        fps: int = -1,
+        max_duration: int = 300,
+        frame_recovery: bool = False,
+        **kwargs,
+    ) -> tuple[npt.NDArray, dict[str, Any]]:
+        frames, metadata = OpenCVVideoBackend.load_bytes(
+            data,
+            num_frames=num_frames,
+            fps=fps,
+            max_duration=max_duration,
+            frame_recovery=frame_recovery,
+            **kwargs,
+        )
+
+        metadata = dict(metadata)
+        metadata["original_video_bytes"] = data
+
+        return frames, metadata
+
+
 @VIDEO_LOADER_REGISTRY.register("openpangu")
 class OpenCVDynamicOpenPanguVideoBackend(OpenCVVideoBackend):
     @classmethod