diff --git a/tests/compile/fusions_e2e/conftest.py b/tests/compile/fusions_e2e/conftest.py
index 873f92cfe..5716c95bb 100644
--- a/tests/compile/fusions_e2e/conftest.py
+++ b/tests/compile/fusions_e2e/conftest.py
@@ -82,6 +82,10 @@ def run_e2e_fusion_test(monkeypatch, caplog_mp_spawn):
                 f"attention backend '{attn_backend.backend.name}'"
             )
 
+        # TODO: remove this after finishing migration from envs to model kwargs
+        if model_name == "openai/gpt-oss-20b":
+            monkeypatch.setenv("VLLM_USE_FLASHINFER_MOE_MXFP4_MXFP8", "1")
+
         # Disable, compile cache to make sure custom passes run.
         # Otherwise, we can't verify fusion happened through the logs.
         monkeypatch.setenv("VLLM_DISABLE_COMPILE_CACHE", "1")
diff --git a/tests/compile/fusions_e2e/models.py b/tests/compile/fusions_e2e/models.py
index 9d6c20264..1a5f18cc0 100644
--- a/tests/compile/fusions_e2e/models.py
+++ b/tests/compile/fusions_e2e/models.py
@@ -162,3 +162,12 @@ deepseek_v3_fp8 = ModelFusionInfo(
         # async_tp=n_layers * 2,
     ),
 )
+
+gpt_oss_20b = ModelFusionInfo(
+    model_name="openai/gpt-oss-20b",
+    matches=lambda n_layers: Matches(
+        ar_rms_fusion=n_layers * 2 + 1,
+        sequence_parallel=n_layers * 2 + 1,
+        async_tp=n_layers * 2,
+    ),
+)
diff --git a/tests/compile/fusions_e2e/test_tp2_ar_rms.py b/tests/compile/fusions_e2e/test_tp2_ar_rms.py
index 8ffadbfaf..301409b2b 100644
--- a/tests/compile/fusions_e2e/test_tp2_ar_rms.py
+++ b/tests/compile/fusions_e2e/test_tp2_ar_rms.py
@@ -20,6 +20,7 @@ from .models import (
     FLASHINFER_MLA_ATTN,
     TRITON_ATTN,
     deepseek_v3_fp8,
+    gpt_oss_20b,
     llama3_8b,
     llama3_8b_fp4,
     llama3_8b_fp8,
@@ -158,7 +159,7 @@ def test_tp2_ar_rms_fp4_fusions(
 @multi_gpu_test(num_gpus=2)
 @pytest.mark.parametrize(
     "model_name, matches_fn, model_kwargs, hf_overrides",
-    [llama3_8b, qwen3_a3b],
+    [llama3_8b, qwen3_a3b, gpt_oss_20b],
 )
 @pytest.mark.parametrize("attn_backend", [TRITON_ATTN])
 @pytest.mark.parametrize("n_layers", [4])
diff --git a/vllm/model_executor/layers/fused_moe/fused_moe_method_base.py b/vllm/model_executor/layers/fused_moe/fused_moe_method_base.py
index 88cd173fe..f6a303e79 100644
--- a/vllm/model_executor/layers/fused_moe/fused_moe_method_base.py
+++ b/vllm/model_executor/layers/fused_moe/fused_moe_method_base.py
@@ -101,6 +101,11 @@ class FusedMoEMethodBase(QuantizeMethodBase):
             return self.moe_kernel.prepare_finalize.topk_indices_dtype()
         return None
 
+    @property
+    def skip_forward_padding(self) -> bool:
+        """Whether to skip the padding in the forward before applying the moe method."""
+        return False
+
     @property
     def supports_eplb(self) -> bool:
         return False
diff --git a/vllm/model_executor/layers/fused_moe/runner/default_moe_runner.py b/vllm/model_executor/layers/fused_moe/runner/default_moe_runner.py
index b6313776e..12b560493 100644
--- a/vllm/model_executor/layers/fused_moe/runner/default_moe_runner.py
+++ b/vllm/model_executor/layers/fused_moe/runner/default_moe_runner.py
@@ -415,7 +415,10 @@ class DefaultMoERunner(MoERunner):
 
         # This is the dimension after transform (for routed expert output slicing)
         transformed_hidden_dim = hidden_states.shape[-1]
-        if self.moe_config.hidden_dim != transformed_hidden_dim:
+        if (
+            not self.quant_method.skip_forward_padding
+            and self.moe_config.hidden_dim != transformed_hidden_dim
+        ):
             hidden_states = F.pad(
                 hidden_states,
                 (0, self.moe_config.hidden_dim - transformed_hidden_dim),
diff --git a/vllm/model_executor/layers/quantization/mxfp4.py b/vllm/model_executor/layers/quantization/mxfp4.py
index 1ad024a6f..f992d0f86 100644
--- a/vllm/model_executor/layers/quantization/mxfp4.py
+++ b/vllm/model_executor/layers/quantization/mxfp4.py
@@ -294,6 +294,12 @@ class Mxfp4MoEMethod(FusedMoEMethodBase):
         # Initialized in process_weights_after_loading for CUTLASS/SM90 backends
         self.moe_kernel: mk.FusedMoEKernel | None = None
 
+    @property
+    def skip_forward_padding(self) -> bool:
+        # SM100_FI_MXFP4_MXFP8_TRTLLM supports padding with mxfp8 quant
+        # so can skip the padding in the forward before applying the moe method
+        return self.mxfp4_backend == Mxfp4Backend.SM100_FI_MXFP4_MXFP8_TRTLLM
+
     def create_weights(
         self,
         layer: torch.nn.Module,
@@ -1130,9 +1136,17 @@ class Mxfp4MoEMethod(FusedMoEMethodBase):
             elif self.mxfp4_backend == Mxfp4Backend.SM100_FI_MXFP4_MXFP8_TRTLLM:
                 from flashinfer import mxfp8_quantize
 
-                x_quant, x_scale = mxfp8_quantize(x, False)  # to mxfp8
+                # x_quant is padded in hidden dimension with alignment=256
+                x_quant, x_scale = mxfp8_quantize(
+                    x,
+                    is_sf_swizzled_layout=False,
+                    alignment=256,
+                )
                 x_scale = x_scale.view(torch.float8_e4m3fn).reshape(*x.shape[:-1], -1)
 
+            # output with original unpadded hidden size
+            output = torch.empty_like(x)
+
             trtllm_gen_output = trtllm_fp4_block_scale_moe(
                 routing_logits=router_logits.to(torch.bfloat16),
                 routing_bias=None,
@@ -1161,6 +1175,7 @@ class Mxfp4MoEMethod(FusedMoEMethodBase):
                 routing_method_type=1 if layer.renormalize else 0,
                 do_finalize=True,
                 tune_max_num_tokens=max(self.max_capture_size, 1),
+                output=output,
             )[0]
             return trtllm_gen_output
         elif self.mxfp4_backend == Mxfp4Backend.CK: