diff --git a/tests/v1/worker/test_gpu_model_runner.py b/tests/v1/worker/test_gpu_model_runner.py
index 02fac6dfc..0fbd6605a 100644
--- a/tests/v1/worker/test_gpu_model_runner.py
+++ b/tests/v1/worker/test_gpu_model_runner.py
@@ -1,6 +1,8 @@
 # SPDX-License-Identifier: Apache-2.0
 # SPDX-FileCopyrightText: Copyright contributors to the vLLM project
 
+from types import SimpleNamespace
+
 import numpy as np
 import pytest
 import torch
@@ -30,6 +32,7 @@ from vllm.v1.attention.backends.registry import AttentionBackendEnum
 from vllm.v1.core.kv_cache_utils import estimate_max_model_len, get_kv_cache_configs
 from vllm.v1.core.sched.output import CachedRequestData, NewRequestData, SchedulerOutput
 from vllm.v1.kv_cache_interface import (
+    AttentionSpec,
     FullAttentionSpec,
     KVCacheConfig,
     KVCacheGroupSpec,
@@ -38,7 +41,7 @@ from vllm.v1.kv_cache_interface import (
 from vllm.v1.sample.metadata import SamplingMetadata
 from vllm.v1.worker.gpu_input_batch import InputBatch
 from vllm.v1.worker.gpu_model_runner import GPUModelRunner
-from vllm.v1.worker.utils import select_common_block_size
+from vllm.v1.worker.utils import AttentionGroup, select_common_block_size
 
 BLOCK_SIZE = 16
 NUM_BLOCKS = 10
@@ -946,6 +949,33 @@ def test_hybrid_attention_mamba_tensor_shapes():
             assert torch.equal(actual_ssm, expected_ssm)
 
 
+def test_update_hybrid_attention_mamba_layout_with_num_block_2_rewrites_stride():
+    from vllm.v1.attention.backends.flash_attn import FlashAttentionBackend
+
+    ambiguous_cache = torch.empty((2, 2, BLOCK_SIZE, 1, 8), dtype=torch.float16)
+    """Ambiguous, because both dims[0=kv_dim] and dims[1=num_blocks] == 2"""
+    hidden_size = ambiguous_cache.shape[2:].numel()
+    assert ambiguous_cache.stride()[:2] == (2 * hidden_size, hidden_size)
+
+    attention_spec = AttentionSpec(
+        block_size=BLOCK_SIZE, num_kv_heads=1, head_size=8, dtype=torch.float16
+    )
+    runner_stub = SimpleNamespace(
+        cache_config=SimpleNamespace(cache_dtype="auto"),
+        _kv_cache_spec_attn_group_iterator=lambda: iter(
+            [AttentionGroup(FlashAttentionBackend, ["attn"], attention_spec, 0)]
+        ),
+    )
+    GPUModelRunner._update_hybrid_attention_mamba_layout(
+        runner_stub, {"attn": ambiguous_cache}, [BLOCK_SIZE]
+    )
+
+    assert ambiguous_cache.stride()[:2] == (hidden_size, 2 * hidden_size), """\
+        We expect _update_hybrid_attention_mamba_layout to re-stride the cache from:
+        (2, num_blocks) -> (num_blocks, 2), even when num_blocks==2, 
+        which was ambiguous before get_kv_cache_block_dim was used"""
+
+
 def test_hybrid_block_table_initialization():
     """Test hybrid block table with different kernel and kvcache_manager block
     sizes."""
diff --git a/vllm/v1/worker/gpu_model_runner.py b/vllm/v1/worker/gpu_model_runner.py
index 8cfa61baa..1f946cda0 100644
--- a/vllm/v1/worker/gpu_model_runner.py
+++ b/vllm/v1/worker/gpu_model_runner.py
@@ -6653,12 +6653,12 @@ class GPUModelRunner(
                     raise NotImplementedError
 
         if has_attn and has_mamba:
-            self._update_hybrid_attention_mamba_layout(kv_caches)
+            self._update_hybrid_attention_mamba_layout(kv_caches, kernel_block_sizes)
 
         return kv_caches
 
     def _update_hybrid_attention_mamba_layout(
-        self, kv_caches: dict[str, torch.Tensor]
+        self, kv_caches: dict[str, torch.Tensor], kernel_block_sizes: list[int]
     ) -> None:
         """
         Update the layout of attention layers from (2, num_blocks, ...) to
@@ -6666,23 +6666,30 @@ class GPUModelRunner(
 
         Args:
             kv_caches: The KV cache buffer of each layer.
+            kernel_block_sizes: The kernel block sizes for each KV cache group.
         """
 
         for group in self._kv_cache_spec_attn_group_iterator():
             kv_cache_spec = group.kv_cache_spec
+            if not isinstance(kv_cache_spec, AttentionSpec):
+                continue
+            block_dim = group.backend.get_kv_cache_block_dim(
+                kernel_block_sizes[group.kv_cache_group_id],
+                kv_cache_spec.num_kv_heads,
+                kv_cache_spec.head_size,
+                cache_dtype_str=self.cache_config.cache_dtype,
+            )
+            # block_dim: 0 means (num_blocks, 2, ...); 1 means (2, num_blocks, ...).
+            if block_dim == 0:
+                continue
+            assert block_dim == 1
             for layer_name in group.layer_names:
                 kv_cache = kv_caches[layer_name]
-                if isinstance(kv_cache_spec, AttentionSpec) and kv_cache.shape[0] == 2:
-                    assert kv_cache.shape[1] != 2, (
-                        "Fail to determine whether the layout is "
-                        "(2, num_blocks, ...) or (num_blocks, 2, ...) for "
-                        f"a tensor of shape {kv_cache.shape}"
-                    )
-                    hidden_size = kv_cache.shape[2:].numel()
-                    kv_cache.as_strided_(
-                        size=kv_cache.shape,
-                        stride=(hidden_size, 2 * hidden_size, *kv_cache.stride()[2:]),
-                    )
+                hidden_size = kv_cache.shape[2:].numel()
+                kv_cache.as_strided_(
+                    size=kv_cache.shape,
+                    stride=(hidden_size, 2 * hidden_size, *kv_cache.stride()[2:]),
+                )
 
     def initialize_kv_cache_tensors(
         self, kv_cache_config: KVCacheConfig, kernel_block_sizes: list[int]